Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM51065
Substrate
n/a
Meas. Tech.
uHTS absorbance assay for the identification of compounds that inhibit VHR1.
IC50
4250±n/a nM
Citation
 PubChem, PC uHTS absorbance assay for the identification of compounds that inhibit VHR1. PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM51065
Synonyms:
(4-Methyl-2-oxo-2H-chromen-7-yloxy)-acetic acid [1-(2-hydroxy-5-nitro-phenyl)-meth-(E)-ylidene]-hydrazide | 2-(2-keto-4-methyl-chromen-7-yl)oxy-N'-[(E)-(6-keto-3-nitro-cyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide | 2-(4-methyl-2-oxidanylidene-chromen-7-yl)oxy-N'-[(E)-(3-nitro-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]ethanehydrazide | 2-(4-methyl-2-oxochromen-7-yl)oxy-N'-[(E)-(3-nitro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide | 2-[(4-methyl-2-oxo-1-benzopyran-7-yl)oxy]-N'-[(E)-(3-nitro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]acetohydrazide | MLS000588734 | SMR000212423 | cid_5521841
Type:
Small organic molecule
Emp. Form.:
C19H15N3O7
Mol. Mass.:
397.3383
SMILES:
Cc1cc(=O)oc2cc(OCC(=O)N\[NH+]=C\[c-]3cc(ccc3=O)[N+]([O-])=O)ccc12
Structure:
Search PDB for entries with ligand similarity: