Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61281
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
13340±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61281
Synonyms:
2-[(6-ethoxy-1H-benzimidazol-2-yl)sulfanyl]-N-(furan-2-ylmethylcarbamoyl)acetamide | 2-[(6-ethoxy-1H-benzimidazol-2-yl)sulfanyl]-N-(furan-2-ylmethylcarbamoyl)ethanamide | 2-[(6-ethoxy-1H-benzimidazol-2-yl)thio]-N-(2-furfurylcarbamoyl)acetamide | 2-[(6-ethoxy-1H-benzimidazol-2-yl)thio]-N-[(2-furanylmethylamino)-oxomethyl]acetamide | MLS000568562 | SMR000154729 | cid_2517341
Type:
Small organic molecule
Emp. Form.:
C17H18N4O4S
Mol. Mass.:
374.414
SMILES:
CCOc1ccc2nc(SCC(=O)NC(=O)NCc3ccco3)[nH]c2c1
Structure:
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