Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM58245
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
8230±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM58245
Synonyms:
5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-(3-methyl-1-piperidinyl)-3-oxopropyl]-4-phenyl-1-benzopyran-2-one | 5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-(3-methylpiperidin-1-yl)-3-oxidanylidene-propyl]-4-phenyl-chromen-2-one | 5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-(3-methylpiperidin-1-yl)-3-oxopropyl]-4-phenylchromen-2-one | 8-[3-keto-1-(4-methoxyphenyl)-3-(3-methylpiperidino)propyl]-5,7-dimethoxy-4-phenyl-coumarin | MLS000879485 | SMR000465527 | cid_16746302
Type:
Small organic molecule
Emp. Form.:
C33H35NO6
Mol. Mass.:
541.6341
SMILES:
COc1ccc(cc1)C(CC(=O)N1CCCC(C)C1)c1c(OC)cc(OC)c2c(cc(=O)oc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: