Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61366
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
100000±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61366
Synonyms:
(4S,5R,6R)-1-ethyl-2-(2-methoxyethylamino)-6-methyl-4-(2-phenylethyl)-5,6-dihydro-4H-pyrimidine-5-carboxylic acid methyl ester | (4S,5R,6R)-1-ethyl-2-(2-methoxyethylamino)-6-methyl-4-phenethyl-5,6-dihydro-4H-pyrimidine-5-carboxylic acid methyl ester | MLS000829915 | SMR000672027 | cid_24789243 | methyl (4S,5R,6R)-1-ethyl-2-(2-methoxyethylamino)-6-methyl-4-(2-phenylethyl)-5,6-dihydro-4H-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H31N3O3
Mol. Mass.:
361.4784
SMILES:
CCN1[C@H](C)[C@H]([C@H](CCc2ccccc2)N=C1NCCOC)C(=O)OC |c:16|
Structure:
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