Reaction Details Report a problem with these data
Target
NADPH oxidase 1
Ligand
BDBM65845
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1)
IC50
464±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1) PubChem Bioassay (2010)[AID] 
Target
Name:
NADPH oxidase 1
Synonyms:
MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN
Type:
PROTEIN
Mol. Mass.:
64890.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792877
Residue:
564
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
  
Inhibitor
Name:
BDBM65845
Synonyms:
1-[4-(dimethylamino)phenyl]-3-(1-naphthalenyl)urea | 1-[4-(dimethylamino)phenyl]-3-(1-naphthyl)urea | 1-[4-(dimethylamino)phenyl]-3-naphthalen-1-yl-urea | 1-[4-(dimethylamino)phenyl]-3-naphthalen-1-ylurea | SR-01000301119 | SR-01000301119-3 | cid_1259066
Type:
Small organic molecule
Emp. Form.:
C19H19N3O
Mol. Mass.:
305.3737
SMILES:
CN(C)c1ccc(NC(=O)Nc2cccc3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: