Reaction Details Report a problem with these data
Target
NADPH oxidase 1
Ligand
BDBM46746
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1)
IC50
187±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1) PubChem Bioassay (2010)[AID] 
Target
Name:
NADPH oxidase 1
Synonyms:
MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN
Type:
PROTEIN
Mol. Mass.:
64890.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792877
Residue:
564
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
  
Inhibitor
Name:
BDBM46746
Synonyms:
1-(1,2,3-benzothiadiazol-5-yl)-3-[4-(dimethylamino)phenyl]urea | 1-Benzo[1,2,3]thiadiazol-5-yl-3-(4-dimethylamino-phenyl)-urea | MLS000073076 | SMR000012795 | cid_647195
Type:
Small organic molecule
Emp. Form.:
C15H15N5OS
Mol. Mass.:
313.378
SMILES:
CN(C)c1ccc(NC(=O)Nc2ccc3snnc3c2)cc1
Structure:
Search PDB for entries with ligand similarity: