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Target
NADPH oxidase 1
Ligand
BDBM65954
Substrate
n/a
Meas. Tech.
Late-stage luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1): Synthesized analogs
IC50
382±n/a nM
Citation
 PubChem, PC Late-stage luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1): Synthesized analogs PubChem Bioassay (2010)[AID] 
Target
Name:
NADPH oxidase 1
Synonyms:
MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN
Type:
PROTEIN
Mol. Mass.:
64890.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792877
Residue:
564
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
  
Inhibitor
Name:
BDBM65954
Synonyms:
4-hydroxy-N-[(E)-1-(10H-phenothiazin-2-yl)ethylideneamino]benzamide | 4-hydroxy-N-[1-(10H-phenothiazin-2-yl)ethylideneamino]benzamide | 4-oxidanyl-N-[1-(10H-phenothiazin-2-yl)ethylideneamino]benzamide | SR-01000697372 | SR-01000697372-3 | cid_3307928
Type:
Small organic molecule
Emp. Form.:
C21H17N3O2S
Mol. Mass.:
375.444
SMILES:
CC(=NNC(=O)c1ccc(O)cc1)c1ccc2Sc3ccccc3Nc2c1 |w:2.2|
Structure:
Search PDB for entries with ligand similarity: