Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM52141
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
18300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM52141
Synonyms:
2-[(1-oxo-2-phenoxyethyl)amino]propanoic acid [2-(2-benzofuranyl)-2-oxoethyl] ester | 2-[(2-phenoxyacetyl)amino]propionic acid [2-(benzofuran-2-yl)-2-keto-ethyl] ester | MLS000057997 | SMR000063043 | [2-(1-benzofuran-2-yl)-2-oxidanylidene-ethyl] 2-(2-phenoxyethanoylamino)propanoate | [2-(1-benzofuran-2-yl)-2-oxoethyl] 2-[(2-phenoxyacetyl)amino]propanoate | cid_2998385
Type:
Small organic molecule
Emp. Form.:
C21H19NO6
Mol. Mass.:
381.3787
SMILES:
CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1
Structure:
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