Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM67185
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
28700±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM67185
Synonyms:
2-{3-nitrophenyl}-2-oxoethyl 4-(2-chloroanilino)-4-oxobutanoate | 4-(2-chloroanilino)-4-keto-butyric acid [2-keto-2-(3-nitrophenyl)ethyl] ester | 4-(2-chloroanilino)-4-oxobutanoic acid [2-(3-nitrophenyl)-2-oxoethyl] ester | MLS000324505 | SMR000164151 | [2-(3-nitrophenyl)-2-oxidanylidene-ethyl] 4-[(2-chlorophenyl)amino]-4-oxidanylidene-butanoate | [2-(3-nitrophenyl)-2-oxoethyl] 4-(2-chloroanilino)-4-oxobutanoate | cid_1726745
Type:
Small organic molecule
Emp. Form.:
C18H15ClN2O6
Mol. Mass.:
390.775
SMILES:
[O-][N+](=O)c1cccc(c1)C(=O)COC(=O)CCC(=O)Nc1ccccc1Cl
Structure:
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