Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM67281
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
35300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM67281
Synonyms:
1-[[3-chloranyl-5-(trifluoromethyl)pyridin-2-yl]amino]-3-pyridin-3-yl-thiourea | 1-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-(3-pyridinyl)thiourea | 1-[[3-chloro-5-(trifluoromethyl)-2-pyridyl]amino]-3-(3-pyridyl)thiourea | 1-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino]-3-pyridin-3-ylthiourea | MLS000517535 | SMR000343549 | cid_2476054
Type:
Small organic molecule
Emp. Form.:
C12H9ClF3N5S
Mol. Mass.:
347.747
SMILES:
FC(F)(F)c1cnc(NNC(=S)Nc2cccnc2)c(Cl)c1
Structure:
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