Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM68048
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
5910±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM68048
Synonyms:
(7-chloro-4-nitro-benzofurazan-5-yl)amine | 7-Chloro-4-nitro-benzo[1,2,5]oxadiazol-5-ylamine | 7-chloranyl-4-nitro-2,1,3-benzoxadiazol-5-amine | 7-chloro-4-nitro-2,1,3-benzoxadiazol-5-amine | MLS000580319 | SMR000220484 | cid_2735302
Type:
Small organic molecule
Emp. Form.:
C6H3ClN4O3
Mol. Mass.:
214.566
SMILES:
Nc1cc(Cl)c2nonc2c1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: