Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM63274
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
>10000±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM63274
Synonyms:
MLS000678904 | N-(3-maleimidophenyl)-2-phenyl-acetamide | N-[3-(2,5-dioxo-1-pyrrolyl)phenyl]-2-phenylacetamide | N-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]-2-phenylacetamide | N-[3-(2,5-dioxopyrrol-1-yl)phenyl]-2-phenylacetamide | N-[3-[2,5-bis(oxidanylidene)pyrrol-1-yl]phenyl]-2-phenyl-ethanamide | SMR000269957 | cid_885806
Type:
Small organic molecule
Emp. Form.:
C18H14N2O3
Mol. Mass.:
306.3154
SMILES:
O=C(Cc1ccccc1)Nc1cccc(c1)N1C(=O)C=CC1=O |c:21|
Structure:
Search PDB for entries with ligand similarity: