Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM68080
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
1840±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM68080
Synonyms:
4,5-bis(bromanyl)-2-(4,6-dimethoxypyrimidin-2-yl)pyridazin-3-one | 4,5-dibromo-2-(4,6-dimethoxy-2-pyrimidinyl)-3(2H)-pyridazinone | 4,5-dibromo-2-(4,6-dimethoxy-2-pyrimidinyl)-3-pyridazinone | 4,5-dibromo-2-(4,6-dimethoxypyrimidin-2-yl)pyridazin-3-one | MLS000699101 | SMR000229896 | cid_985526
Type:
Small organic molecule
Emp. Form.:
C10H8Br2N4O3
Mol. Mass.:
392.004
SMILES:
COc1cc(OC)nc(n1)-n1ncc(Br)c(Br)c1=O
Structure:
Search PDB for entries with ligand similarity: