Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43723
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify activators of signal transducer and activator of transcription 1 (STAT1)
EC50
>55690±n/a nM
Citation
 PubChem, PC Late stage counterscreen results from the probe development effort to identify activators of signal transducer and activator of transcription 1 (STAT1): luminescence-based cell-based dose response assay for STAT3 activators PubChem Bioassay (2010)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43723
Synonyms:
(E)-1-(4-bromophenyl)-3-(2-fluoroanilino)-2-propen-1-one | (E)-1-(4-bromophenyl)-3-(2-fluoroanilino)prop-2-en-1-one | (E)-1-(4-bromophenyl)-3-[(2-fluorophenyl)amino]prop-2-en-1-one | 1-(4-bromophenyl)-3-[(2-fluorophenyl)amino]-2-propen-1-one | MLS000686553 | SMR000268204 | cid_2267974
Type:
Small organic molecule
Emp. Form.:
C15H11BrFNO
Mol. Mass.:
320.156
SMILES:
Fc1ccccc1N=CCC(=O)c1ccc(Br)cc1 |w:7.7|
Structure:
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