Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM72302
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
17140±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM72302
Synonyms:
2-(N-(4-chloro-3-nitro-phenyl)sulfonyl-2,4-dimethyl-anilino)-N-[2-(4-fluorophenyl)ethyl]acetamide | 2-(N-(4-chloro-3-nitrophenyl)sulfonyl-2,4-dimethylanilino)-N-[2-(4-fluorophenyl)ethyl]acetamide | 2-[(4-chloranyl-3-nitro-phenyl)sulfonyl-(2,4-dimethylphenyl)amino]-N-[2-(4-fluorophenyl)ethyl]ethanamide | MLS000339653 | SMR000242070 | cid_3973468
Type:
Small organic molecule
Emp. Form.:
C24H23ClFN3O5S
Mol. Mass.:
519.973
SMILES:
Cc1ccc(N(CC(=O)NCCc2ccc(F)cc2)S(=O)(=O)c2ccc(Cl)c(c2)[N+]([O-])=O)c(C)c1
Structure:
Search PDB for entries with ligand similarity: