Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM52141
Substrate
n/a
Meas. Tech.
Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50
13817±1186 nM
Citation
 PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM52141
Synonyms:
2-[(1-oxo-2-phenoxyethyl)amino]propanoic acid [2-(2-benzofuranyl)-2-oxoethyl] ester | 2-[(2-phenoxyacetyl)amino]propionic acid [2-(benzofuran-2-yl)-2-keto-ethyl] ester | MLS000057997 | SMR000063043 | [2-(1-benzofuran-2-yl)-2-oxidanylidene-ethyl] 2-(2-phenoxyethanoylamino)propanoate | [2-(1-benzofuran-2-yl)-2-oxoethyl] 2-[(2-phenoxyacetyl)amino]propanoate | cid_2998385
Type:
Small organic molecule
Emp. Form.:
C21H19NO6
Mol. Mass.:
381.3787
SMILES:
CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1
Structure:
Search PDB for entries with ligand similarity: