Target
Type-1 angiotensin II receptor
Ligand
BDBM67185
Substrate
n/a
Meas. Tech.
Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50
15047±5827 nM
Citation
 PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM67185
Synonyms:
2-{3-nitrophenyl}-2-oxoethyl 4-(2-chloroanilino)-4-oxobutanoate | 4-(2-chloroanilino)-4-keto-butyric acid [2-keto-2-(3-nitrophenyl)ethyl] ester | 4-(2-chloroanilino)-4-oxobutanoic acid [2-(3-nitrophenyl)-2-oxoethyl] ester | MLS000324505 | SMR000164151 | [2-(3-nitrophenyl)-2-oxidanylidene-ethyl] 4-[(2-chlorophenyl)amino]-4-oxidanylidene-butanoate | [2-(3-nitrophenyl)-2-oxoethyl] 4-(2-chloroanilino)-4-oxobutanoate | cid_1726745
Type:
Small organic molecule
Emp. Form.:
C18H15ClN2O6
Mol. Mass.:
390.775
SMILES:
[O-][N+](=O)c1cccc(c1)C(=O)COC(=O)CCC(=O)Nc1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: