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Target
Lysine-specific histone demethylase 1A [151-852]
Ligand
BDBM103889
Substrate
n/a
Meas. Tech.
Demethylase Biochemical Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<50±n/a nM
Comments
extracted
Citation
 Wu, L; Konkol, LC; Lajkiewicz, N; Lu, L; Xu, M; Yao, W; Yu, Z; Zhang, C; He, C Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors US Patent  US9695168 Publication Date 7/4/2017 
Target
Name:
Lysine-specific histone demethylase 1A [151-852]
Synonyms:
AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific histone demethylase 1A
Type:
n/a
Mol. Mass.:
77867.68
Organism:
Homo sapiens (Human)
Description:
ENZO (BML-SE544-0050) which consists of 151-852 aa
Residue:
702
Sequence:
LPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM103889
Synonyms:
US10047086, 3 | US10640503, Example 3 | US9695168, 3
Type:
Small organic molecule
Emp. Form.:
C25H24N4O3
Mol. Mass.:
428.4831
SMILES:
Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(cc1)[N+]([O-])=O |r|
Structure:
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