Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM76130
Substrate
n/a
Meas. Tech.
Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM76130
Synonyms:
(2-cyclopentyl-7-methyl-6,8-dioxo-3-thiophen-3-ylisoquinolin-7-yl) cyclopentanecarboxylate | CMLD004097 | MLS000438616 | SMR000452667 | [2-cyclopentyl-7-methyl-6,8-bis(oxidanylidene)-3-thiophen-3-yl-isoquinolin-7-yl] cyclopentanecarboxylate | cid_16745637 | cyclopentanecarboxylic acid [2-cyclopentyl-6,8-diketo-7-methyl-3-(3-thienyl)-7-isoquinolyl] ester | cyclopentanecarboxylic acid [2-cyclopentyl-7-methyl-6,8-dioxo-3-(3-thiophenyl)-7-isoquinolinyl] ester
Type:
Small organic molecule
Emp. Form.:
C25H27NO4S
Mol. Mass.:
437.551
SMILES:
CC1(OC(=O)C2CCCC2)C(=O)C=C2C=C(N(C=C2C1=O)C1CCCC1)c1ccsc1 |c:15,18,t:13|
Structure:
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