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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM75675
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase
IC50
49600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM75675
Synonyms:
1-[2-(3,4-dichlorophenyl)ethanoylamino]-3-(oxolan-2-ylmethyl)thiourea | 1-[[2-(3,4-dichlorophenyl)-1-oxoethyl]amino]-3-(2-oxolanylmethyl)thiourea | 1-[[2-(3,4-dichlorophenyl)acetyl]amino]-3-(oxolan-2-ylmethyl)thiourea | 1-[[2-(3,4-dichlorophenyl)acetyl]amino]-3-(tetrahydrofurfuryl)thiourea | MLS001035791 | SMR000666347 | cid_2954804
Type:
Small organic molecule
Emp. Form.:
C14H17Cl2N3O2S
Mol. Mass.:
362.275
SMILES:
Clc1ccc(CC(=O)NNC(=S)NCC2CCCO2)cc1Cl
Structure:
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