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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM59309
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.
EC50
16200±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM59309
Synonyms:
1-[(2-ethyl-4-hydroxy-1-oxo-5-propoxypentyl)amino]-3-phenylthiourea | 1-[(2-ethyl-4-hydroxy-5-propoxy-pentanoyl)amino]-3-phenyl-thiourea | 1-[(2-ethyl-4-hydroxy-5-propoxypentanoyl)amino]-3-phenylthiourea | 1-[(2-ethyl-4-oxidanyl-5-propoxy-pentanoyl)amino]-3-phenyl-thiourea | MLS000587172 | SMR000211181 | cid_3125279
Type:
Small organic molecule
Emp. Form.:
C17H27N3O3S
Mol. Mass.:
353.48
SMILES:
CCCOCC(O)CC(CC)C(=O)NNC(=S)Nc1ccccc1
Structure:
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