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Target
Caspase-3
Ligand
BDBM76437
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
2230±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM76437
Synonyms:
(3,4-dihydro-2H-naphthalen-1-ylideneamino) 4-fluoranylbenzoate | (3,4-dihydro-2H-naphthalen-1-ylideneamino) 4-fluorobenzoate | 1-{[(4-fluorobenzoyl)oxy]imino}-1,2,3,4-tetrahydronaphthalene | 4-fluorobenzoic acid (3,4-dihydro-2H-naphthalen-1-ylideneamino) ester | 4-fluorobenzoic acid (tetralin-1-ylideneamino) ester | MLS000546852 | SMR000180050 | cid_1489353
Type:
Small organic molecule
Emp. Form.:
C17H14FNO2
Mol. Mass.:
283.297
SMILES:
Fc1ccc(cc1)C(=O)ON=C1CCCc2ccccc12
Structure:
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