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Target
Caspase-3
Ligand
BDBM76475
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
2670±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM76475
Synonyms:
3-(6-Bromo-quinolin-8-ylamino)-3H-isobenzofuran-1-one | 3-[(6-bromanylquinolin-8-yl)amino]-3H-2-benzofuran-1-one | 3-[(6-bromo-8-quinolinyl)amino]-3H-isobenzofuran-1-one | 3-[(6-bromo-8-quinolyl)amino]phthalide | 3-[(6-bromoquinolin-8-yl)amino]-3H-2-benzofuran-1-one | MLS000590101 | SMR000219262 | cid_4653365
Type:
Small organic molecule
Emp. Form.:
C17H11BrN2O2
Mol. Mass.:
355.185
SMILES:
Brc1cc(NC2OC(=O)c3ccccc23)c2ncccc2c1
Structure:
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