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Target
Caspase-3
Ligand
BDBM49717
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
4380±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM49717
Synonyms:
2-[1-(4-methoxyanilino)ethylidene]indene-1,3-dione | 2-[1-(p-anisidino)ethylidene]indane-1,3-quinone | 2-[1-[(4-methoxyphenyl)amino]ethylidene]indene-1,3-dione | 2-{1-[(4-methoxyphenyl)amino]ethylidene}-1H-indene-1,3(2H)-dione | MLS000666686 | SMR000268612 | cid_879788
Type:
Small organic molecule
Emp. Form.:
C18H15NO3
Mol. Mass.:
293.3166
SMILES:
[#6]-[#8]-c1ccc(-[#7]\[#6](-[#6])=[#6]-2/[#6](=O)-c3ccccc3-[#6]-2=O)cc1
Structure:
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