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Target
Caspase-3
Ligand
BDBM76569
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
2100±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM76569
Synonyms:
(3Z)-1-ethyl-3-(2-quinolinylhydrazinylidene)-2-indolone | (3Z)-1-ethyl-3-(2-quinolylhydrazono)oxindole | (3Z)-1-ethyl-3-(quinolin-2-ylhydrazinylidene)indol-2-one | 1-Ethyl-3-(quinolin-2-yl-hydrazono)-1,3-dihydro-indol-2-one | MLS000778542 | SMR000415336 | cid_6040562
Type:
Small organic molecule
Emp. Form.:
C19H16N4O
Mol. Mass.:
316.3565
SMILES:
CCN1C(=O)C(=NNc2ccc3ccccc3n2)c2ccccc12 |w:6.6|
Structure:
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