Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM54414
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
61800±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM54414
Synonyms:
5-Nitro-furan-2-carboxylic acid (4-chloro-benzothiazol-2-yl)-amide | MLS001204059 | N-(4-chloranyl-1,3-benzothiazol-2-yl)-5-nitro-furan-2-carboxamide | N-(4-chloro-1,3-benzothiazol-2-yl)-5-nitro-2-furamide | N-(4-chloro-1,3-benzothiazol-2-yl)-5-nitro-2-furancarboxamide | N-(4-chloro-1,3-benzothiazol-2-yl)-5-nitrofuran-2-carboxamide | SMR000524443 | cid_958637
Type:
Small organic molecule
Emp. Form.:
C12H6ClN3O4S
Mol. Mass.:
323.712
SMILES:
[O-][N+](=O)c1ccc(o1)C(=O)Nc1nc2c(Cl)cccc2s1
Structure:
Search PDB for entries with ligand similarity: