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Target
Sentrin-specific protease 8
Ligand
BDBM76475
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay
IC50
1630±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM76475
Synonyms:
3-(6-Bromo-quinolin-8-ylamino)-3H-isobenzofuran-1-one | 3-[(6-bromanylquinolin-8-yl)amino]-3H-2-benzofuran-1-one | 3-[(6-bromo-8-quinolinyl)amino]-3H-isobenzofuran-1-one | 3-[(6-bromo-8-quinolyl)amino]phthalide | 3-[(6-bromoquinolin-8-yl)amino]-3H-2-benzofuran-1-one | MLS000590101 | SMR000219262 | cid_4653365
Type:
Small organic molecule
Emp. Form.:
C17H11BrN2O2
Mol. Mass.:
355.185
SMILES:
Brc1cc(NC2OC(=O)c3ccccc23)c2ncccc2c1
Structure:
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