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Target
Sentrin-specific protease 8
Ligand
BDBM64780
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay
IC50
>5000±0 nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay PubChem Bioassay (2010)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM64780
Synonyms:
4-Methyl-benzoic acid N'-(2,6-di-pyrrolidin-1-yl-pyrimidin-4-yl)-hydrazide | MLS000551080 | N'-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)-4-methyl-benzohydrazide | N'-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)-4-methylbenzohydrazide | N'-(2,6-dipyrrolidinopyrimidin-4-yl)-4-methyl-benzohydrazide | N'-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-4-methylbenzohydrazide | SMR000176238 | cid_1109408
Type:
Small organic molecule
Emp. Form.:
C20H26N6O
Mol. Mass.:
366.46
SMILES:
Cc1ccc(cc1)C(=O)NNc1cc(nc(n1)N1CCCC1)N1CCCC1
Structure:
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