Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78206
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
31900±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78206
Synonyms:
MLS000331812 | Methanesulfonic acid 3-oxo-2-[1-m-tolyl-meth-(Z)-ylidene]-2,3-dihydro-benzofuran-6-yl ester | SMR000221262 | [(2Z)-2-[(3-methylphenyl)methylidene]-3-oxidanylidene-1-benzofuran-6-yl] methanesulfonate | [(2Z)-2-[(3-methylphenyl)methylidene]-3-oxo-1-benzofuran-6-yl] methanesulfonate | cid_2039338 | methanesulfonic acid [(2Z)-2-[(3-methylphenyl)methylidene]-3-oxo-6-benzofuranyl] ester | methanesulfonic acid [(2Z)-3-keto-2-(3-methylbenzylidene)coumaran-6-yl] ester
Type:
Small organic molecule
Emp. Form.:
C17H14O5S
Mol. Mass.:
330.355
SMILES:
Cc1cccc(\C=C2/Oc3cc(OS(C)(=O)=O)ccc3C2=O)c1
Structure:
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