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Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM54748
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay
IC50
>20000±0 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay PubChem Bioassay (2011)[AID] 
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM54748
Synonyms:
3-hydroxy-6-(hydroxymethyl)-2-(pyridin-2-yl{[3-(trifluoromethyl)phenyl]amino}methyl)-4H-pyran-4-one | 3-hydroxy-6-(hydroxymethyl)-2-[2-pyridinyl-[3-(trifluoromethyl)anilino]methyl]-4-pyranone | 3-hydroxy-6-(hydroxymethyl)-2-[pyridin-2-yl-[3-(trifluoromethyl)anilino]methyl]pyran-4-one | 3-hydroxy-6-methylol-2-[2-pyridyl-[3-(trifluoromethyl)anilino]methyl]pyran-4-one | 6-(hydroxymethyl)-3-oxidanyl-2-[pyridin-2-yl-[[3-(trifluoromethyl)phenyl]amino]methyl]pyran-4-one | MLS000766783 | SMR000339679 | cid_4172393
Type:
Small organic molecule
Emp. Form.:
C19H15F3N2O4
Mol. Mass.:
392.3286
SMILES:
OCc1cc(=O)c(O)c(o1)C(Nc1cccc(c1)C(F)(F)F)c1ccccn1
Structure:
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