Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77817
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77817
Synonyms:
(E)-3-(2-chlorophenyl)-N-phenyl-2-propenamide | (E)-3-(2-chlorophenyl)-N-phenyl-acrylamide | (E)-3-(2-chlorophenyl)-N-phenyl-prop-2-enamide | (E)-3-(2-chlorophenyl)-N-phenylprop-2-enamide | MLS000859034 | N1-phenyl-3-(2-chlorophenyl)acrylamide | SMR000459213 | cid_737170
Type:
Small organic molecule
Emp. Form.:
C15H12ClNO
Mol. Mass.:
257.715
SMILES:
Clc1ccccc1\C=C\C(=O)Nc1ccccc1
Structure:
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