Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM58626
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM58626
Synonyms:
5-chloro-N-[4-(difluoromethoxy)phenyl]-2-(4-methylbenzyl)sulfonyl-pyrimidine-4-carboxamide | 5-chloro-N-[4-(difluoromethoxy)phenyl]-2-[(4-methylphenyl)methylsulfonyl]-4-pyrimidinecarboxamide | 5-chloro-N-[4-(difluoromethoxy)phenyl]-2-[(4-methylphenyl)methylsulfonyl]pyrimidine-4-carboxamide | MLS001116167 | N-[4-[bis(fluoranyl)methoxy]phenyl]-5-chloranyl-2-[(4-methylphenyl)methylsulfonyl]pyrimidine-4-carboxamide | SMR000625781 | cid_16446215
Type:
Small organic molecule
Emp. Form.:
C20H16ClF2N3O4S
Mol. Mass.:
467.874
SMILES:
Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(n2)C(=O)Nc2ccc(OC(F)F)cc2)cc1
Structure:
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