Reaction Details Report a problem with these data
Target
Tropomyosin alpha-1 chain
Ligand
BDBM79646
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
>2648±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM79646
Synonyms:
6-fluoranyl-4-oxidanidyl-7-pyrrolidin-1-yl-2,3-dihydro-1H-cyclopenta[b]quinoxalin-9-ium 9-oxide | 6-fluoro-4-oxido-7-(1-pyrrolidinyl)-2,3-dihydro-1H-cyclopenta[b]quinoxalin-9-ium 9-oxide | 6-fluoro-4-oxido-7-pyrrolidin-1-yl-2,3-dihydro-1H-cyclopenta[b]quinoxalin-9-ium 9-oxide | 6-fluoro-4-oxido-7-pyrrolidino-2,3-dihydro-1H-cyclopenta[b]quinoxalin-9-ium 9-oxide | 6-fluoro-7-pyrrolidin-1-yl-2,3-dihydro-1H-cyclopenta[b]quinoxaline 4,9-dioxide | MLS000045751 | SMR000027708 | cid_3242663
Type:
Small organic molecule
Emp. Form.:
C15H16FN3O2
Mol. Mass.:
289.3048
SMILES:
[O-]N1C2=C(CCC2)[N+](=O)c2cc(N3CCCC3)c(F)cc12 |t:2|
Structure:
Search PDB for entries with ligand similarity: