Reaction Details Report a problem with these data
Target
Tropomyosin alpha-1 chain
Ligand
BDBM79672
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
760.72±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM79672
Synonyms:
(E)-2-[4-(3-bromophenyl)-1,3-thiazol-2-yl]-3-[(4-methylpyridin-2-yl)amino]prop-2-enenitrile | (E)-2-[4-(3-bromophenyl)-2-thiazolyl]-3-[(4-methyl-2-pyridinyl)amino]-2-propenenitrile | (E)-2-[4-(3-bromophenyl)thiazol-2-yl]-3-[(4-methyl-2-pyridyl)amino]acrylonitrile | cid_1352154
Type:
Small organic molecule
Emp. Form.:
C18H13BrN4S
Mol. Mass.:
397.292
SMILES:
Cc1ccnc(c1)N=CC(C#N)c1nc(cs1)-c1cccc(Br)c1 |w:7.7|
Structure:
Search PDB for entries with ligand similarity: