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Target
Tropomyosin alpha-1 chain
Ligand
BDBM47264
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
2901±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM47264
Synonyms:
3,6-dihydroxy-5-methyl-2-phenyl-1H-benzo[de]isoquinoline-1,4(2H)-dione | 4,6-dihydroxy-5-methyl-2-phenyl-benzo[de]isoquinoline-1,3-quinone | 4,6-dihydroxy-5-methyl-2-phenylbenzo[de]isoquinoline-1,3-dione | 5-methyl-4,6-bis(oxidanyl)-2-phenyl-benzo[de]isoquinoline-1,3-dione | MLS000704863 | SMR000230433 | cid_5409731
Type:
Small organic molecule
Emp. Form.:
C19H13NO4
Mol. Mass.:
319.3108
SMILES:
Cc1c(O)c2C(=O)N(C(=O)c3cccc(c1O)c23)c1ccccc1
Structure:
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