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Target
Tropomyosin alpha-1 chain
Ligand
BDBM79687
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
164.57±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM79687
Synonyms:
2-[(2Z,5Z)-4-keto-2-(2-keto-3,3-dimethyl-butylidene)-5-[[5-(4-nitrophenyl)-2-furyl]methylene]thiazolidin-3-yl]-N-propyl-acetamide | 2-[2-(3,3-dimethyl-2-oxidanylidene-butylidene)-5-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-4-oxidanylidene-1,3-thiazolidin-3-yl]-N-propyl-ethanamide | 2-[2-(3,3-dimethyl-2-oxobutylidene)-5-[[5-(4-nitrophenyl)-2-furanyl]methylidene]-4-oxo-3-thiazolidinyl]-N-propylacetamide | 2-[2-(3,3-dimethyl-2-oxobutylidene)-5-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-4-oxo-1,3-thiazolidin-3-yl]-N-propylacetamide | 2-[4-keto-2-(2-keto-3,3-dimethyl-butylidene)-5-[[5-(4-nitrophenyl)-2-furyl]methylene]thiazolidin-3-yl]-N-propyl-acetamide | MLS000335381 | SMR000250121 | cid_5025735
Type:
Small organic molecule
Emp. Form.:
C25H27N3O6S
Mol. Mass.:
497.563
SMILES:
CCCNC(=O)Cn1\c(=C\C(=O)C(C)(C)C)s\c(=C/c2ccc(o2)-c2ccc(cc2)[N+]([O-])=O)c1=O
Structure:
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