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Target
Tropomyosin alpha-1 chain
Ligand
BDBM48749
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
1101±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM48749
Synonyms:
(5Z)-5-(2,5-dimethoxy-4-pyrrolidino-benzylidene)-3-ethyl-2-ethylimino-thiazolidin-4-one | (5Z)-5-[(2,5-dimethoxy-4-pyrrolidin-1-yl-phenyl)methylidene]-3-ethyl-2-ethylimino-1,3-thiazolidin-4-one | (5Z)-5-[(2,5-dimethoxy-4-pyrrolidin-1-ylphenyl)methylidene]-3-ethyl-2-ethylimino-1,3-thiazolidin-4-one | (5Z)-5-[[2,5-dimethoxy-4-(1-pyrrolidinyl)phenyl]methylidene]-3-ethyl-2-ethylimino-4-thiazolidinone | 5-[2,5-dimethoxy-4-(1-pyrrolidinyl)benzylidene]-3-ethyl-2-(ethylimino)-1,3-thiazolidin-4-one | MLS000702004 | SMR000228966 | cid_6974996
Type:
Small organic molecule
Emp. Form.:
C20H27N3O3S
Mol. Mass.:
389.512
SMILES:
CC\N=C1\S\C(=C/c2cc(OC)c(cc2OC)N2CCCC2)C(=O)N1CC
Structure:
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