Reaction Details Report a problem with these data
Target
Tropomyosin alpha-1 chain
Ligand
BDBM65365
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
1577±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM65365
Synonyms:
(Z)-2-cyano-N-(4-methoxyphenyl)-3-(5-morpholin-4-ylfuran-2-yl)prop-2-enamide | (Z)-2-cyano-N-(4-methoxyphenyl)-3-(5-morpholino-2-furyl)acrylamide | (Z)-2-cyano-N-(4-methoxyphenyl)-3-[5-(4-morpholinyl)-2-furanyl]-2-propenamide | MLS000712042 | SMR000281809 | cid_1922517
Type:
Small organic molecule
Emp. Form.:
C19H19N3O4
Mol. Mass.:
353.3719
SMILES:
COc1ccc(NC(=O)C(=C/c2ccc(o2)N2CCOCC2)\C#N)cc1
Structure:
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