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Target
Tropomyosin alpha-1 chain
Ligand
BDBM51177
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
4162±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM51177
Synonyms:
2-(2-methyl-4-pyrrolidino-benzylidene)malononitrile | 2-[(2-methyl-4-pyrrolidin-1-yl-phenyl)methylidene]propanedinitrile | 2-[(2-methyl-4-pyrrolidin-1-ylphenyl)methylidene]propanedinitrile | 2-[[2-methyl-4-(1-pyrrolidinyl)phenyl]methylidene]propanedinitrile | MLS000706384 | SMR000288436 | cid_963286
Type:
Small organic molecule
Emp. Form.:
C15H15N3
Mol. Mass.:
237.2997
SMILES:
[#6]-c1cc(ccc1\[#6]=[#6](\C#N)C#N)-[#7]-1-[#6]-[#6]-[#6]-[#6]-1
Structure:
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