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Target
Tropomyosin alpha-1 chain
Ligand
BDBM79726
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
165.07±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM79726
Synonyms:
(E,4Z)-2-acetyl-4-(5,6-diethoxy-3-ethyl-1,3-benzothiazol-2-ylidene)-2-butenoic acid ethyl ester | (E,4Z)-2-acetyl-4-(5,6-diethoxy-3-ethyl-1,3-benzothiazol-2-ylidene)but-2-enoic acid ethyl ester | MLS000723517 | SMR000305112 | cid_2176481 | ethyl (2E,4Z)-2-acetyl-4-(5,6-diethoxy-3-ethyl-1,3-benzothiazol-2(3H)-ylidene)but-2-enoate | ethyl (E,4Z)-2-acetyl-4-(5,6-diethoxy-3-ethyl-1,3-benzothiazol-2-ylidene)but-2-enoate | ethyl (E,4Z)-4-(5,6-diethoxy-3-ethyl-1,3-benzothiazol-2-ylidene)-2-ethanoyl-but-2-enoate
Type:
Small organic molecule
Emp. Form.:
C21H27NO5S
Mol. Mass.:
405.508
SMILES:
CCOC(=O)C(=CC=C1Sc2cc(OCC)c(OCC)cc2N1CC)C(C)=O |w:7.6,5.26|
Structure:
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