Reaction Details Report a problem with these data
Target
Tropomyosin alpha-1 chain
Ligand
BDBM79784
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
1981±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM79784
Synonyms:
6-[2-(3-aminophenyl)ethynyl]-2-[4-(dimethylamino)phenyl]-1-benzopyran-4-one | 6-[2-(3-aminophenyl)ethynyl]-2-[4-(dimethylamino)phenyl]chromen-4-one | 6-[2-(3-aminophenyl)ethynyl]-2-[4-(dimethylamino)phenyl]chromone | MLS002473527 | SMR001397695 | cid_44202189
Type:
Small organic molecule
Emp. Form.:
C25H20N2O2
Mol. Mass.:
380.4385
SMILES:
CN(C)c1ccc(cc1)-c1cc(=O)c2cc(ccc2o1)C#Cc1cccc(N)c1
Structure:
Search PDB for entries with ligand similarity: