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Target
Tropomyosin alpha-1 chain
Ligand
BDBM79791
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
2574±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM79791
Synonyms:
MLS002636842 | N-(2-methoxyphenyl)-2-[2-[(Z)-(2-methylindol-3-ylidene)methyl]hydrazinyl]-5-nitro-benzenesulfonamide | N-(2-methoxyphenyl)-2-[2-[(Z)-(2-methylindol-3-ylidene)methyl]hydrazinyl]-5-nitrobenzenesulfonamide | N-(2-methoxyphenyl)-2-[N'-[(Z)-(2-methylindol-3-ylidene)methyl]hydrazino]-5-nitro-benzenesulfonamide | N-(2-methoxyphenyl)-2-[[(Z)-(2-methyl-3-indolylidene)methyl]hydrazo]-5-nitrobenzenesulfonamide | SMR000152129 | cid_6068981
Type:
Small organic molecule
Emp. Form.:
C23H21N5O5S
Mol. Mass.:
479.508
SMILES:
COc1ccccc1NS(=O)(=O)c1cc(ccc1N=[NH+]Cc1c(C)[n-]c2ccccc12)[N+]([O-])=O |w:18.19|
Structure:
Search PDB for entries with ligand similarity: