Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM33190
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
68900±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM33190
Synonyms:
5-amino-4-[(2-methoxyanilino)-oxomethyl]-3-methyl-2-thiophenecarboxylic acid ethyl ester | 5-amino-4-[(2-methoxyphenyl)carbamoyl]-3-methyl-thiophene-2-carboxylic acid ethyl ester | MLS000766082 | SMR000279788 | cid_828966 | ethyl 5-amino-4-[(2-methoxyphenyl)carbamoyl]-3-methylthiophene-2-carboxylate | ethyl 5-azanyl-4-[(2-methoxyphenyl)carbamoyl]-3-methyl-thiophene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C16H18N2O4S
Mol. Mass.:
334.39
SMILES:
CCOC(=O)c1sc(N)c(C(=O)Nc2ccccc2OC)c1C
Structure:
