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Target
Hyaluronidase-1
Ligand
BDBM81866
Substrate
n/a
Meas. Tech.
Morgan-Elson Assay
pH
3.5±0
Temperature
310.15±0 K
IC50
6.164e+4±n/a nM
Citation
 Olgen, S; Kaessler, A; Nebioglu, D; Jose, J New potent indole derivatives as hyaluronidase inhibitors. Chem Biol Drug Des 70:547-51 (2007) [PubMed]  Article 
Target
Name:
Hyaluronidase-1
Synonyms:
HYAL1 | HYAL1_HUMAN | Hyaluronidase | Hyaluronidase-1 | Hyaluronoglucosaminidase-1 | LUCA1
Type:
Protein
Mol. Mass.:
48369.09
Organism:
Homo sapiens (Human)
Description:
Q1279
Residue:
435
Sequence:
MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW
  
Inhibitor
Name:
BDBM81866
Synonyms:
N-Substituted indole-2- and 3-carboxamide derivative, 16
Type:
Small organic molecule
Emp. Form.:
C23H19FN2O
Mol. Mass.:
358.4082
SMILES:
Fc1ccc(Cn2cc(C(=O)NCc3ccccc3)c3ccccc23)cc1
Structure:
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