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Target
Hepatocyte growth factor receptor [1038-1346]
Ligand
BDBM106730
Substrate
n/a
Meas. Tech.
c-Met In Vitro Kinase Assay
Temperature
303.15±n/a K
IC50
83±n/a nM
Comments
extracted
Citation
 Zhong, B; Shih, C; Yuan, H; Zhou, F Highly selective c-Met inhibitors as anticancer agents US Patent  US9695175 Publication Date 7/4/2017 
Target
Name:
Hepatocyte growth factor receptor [1038-1346]
Synonyms:
Hepatocyte growth factor receptor (MET) | MET | MET_HUMAN
Type:
n/a
Mol. Mass.:
34804.00
Organism:
Homo sapiens (Human)
Description:
c-Met kinase (1038-1346 aa)
Residue:
309
Sequence:
GDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
  
Inhibitor
Name:
BDBM106730
Synonyms:
US9695175, 38
Type:
Small organic molecule
Emp. Form.:
C20H17F3N8
Mol. Mass.:
426.3978
SMILES:
CC(C)n1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1cc2cn(C)nc2cc1F
Structure:
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