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Target
Beta-lactamase
Ligand
BDBM68080
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA)
IC50
>49746±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM68080
Synonyms:
4,5-bis(bromanyl)-2-(4,6-dimethoxypyrimidin-2-yl)pyridazin-3-one | 4,5-dibromo-2-(4,6-dimethoxy-2-pyrimidinyl)-3(2H)-pyridazinone | 4,5-dibromo-2-(4,6-dimethoxy-2-pyrimidinyl)-3-pyridazinone | 4,5-dibromo-2-(4,6-dimethoxypyrimidin-2-yl)pyridazin-3-one | MLS000699101 | SMR000229896 | cid_985526
Type:
Small organic molecule
Emp. Form.:
C10H8Br2N4O3
Mol. Mass.:
392.004
SMILES:
COc1cc(OC)nc(n1)-n1ncc(Br)c(Br)c1=O
Structure:
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