Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM49574
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
23700±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM49574
Synonyms:
(Z)-2-(1,3-benzothiazol-2-yl)-3-(2-furanyl)-2-propenenitrile | (Z)-2-(1,3-benzothiazol-2-yl)-3-(2-furyl)acrylonitrile | (Z)-2-(1,3-benzothiazol-2-yl)-3-(furan-2-yl)prop-2-enenitrile | (Z)-2-Benzothiazol-2-yl-3-furan-2-yl-acrylonitrile | MLS000589637 | SMR000219445 | cid_7441600
Type:
Small organic molecule
Emp. Form.:
C14H8N2OS
Mol. Mass.:
252.291
SMILES:
N#C\C(=C\c1ccco1)c1nc2ccccc2s1
Structure:
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