Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83559
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83559
Synonyms:
(3E)-1H-indole-2,3-dione 3-[(2-fluorophenyl)hydrazone] | 3-[(2-fluorophenyl)hydrazo]-2-indolone | 3-[2-(2-fluorophenyl)hydrazinyl]indol-2-one | 3-[N'-(2-fluorophenyl)hydrazino]indol-2-one | MLS000586496 | SMR000207875 | cid_6072187
Type:
Small organic molecule
Emp. Form.:
C14H10FN3O
Mol. Mass.:
255.2471
SMILES:
Fc1ccccc1NNC1=c2ccccc2=NC1=O |c:10,17|
Structure:
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