Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM61783
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
7090±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM61783
Synonyms:
1-(2,4-dichlorophenyl)-3-[1-(4-fluorophenyl)sulfonyl-4-piperidinyl]urea | 1-(2,4-dichlorophenyl)-3-[1-(4-fluorophenyl)sulfonyl-4-piperidyl]urea | 1-(2,4-dichlorophenyl)-3-[1-(4-fluorophenyl)sulfonylpiperidin-4-yl]urea | MLS000544968 | N-(2,4-dichlorophenyl)-N'-{1-[(4-fluorophenyl)sulfonyl]-4-piperidinyl}urea | SMR000126725 | cid_3562031
Type:
Small organic molecule
Emp. Form.:
C18H18Cl2FN3O3S
Mol. Mass.:
446.323
SMILES:
Fc1ccc(cc1)S(=O)(=O)N1CCC(CC1)NC(=O)Nc1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: