Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM52596
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
15600±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM52596
Synonyms:
3-[(E)-2-(4-fluorophenyl)ethenyl]-1H-quinoxalin-2-one | 3-[(E)-2-(4-fluorophenyl)vinyl]-1H-quinoxalin-2-one | 3-[2-(4-fluorophenyl)vinyl]-2(1H)-quinoxalinone | MLS000663373 | SMR000300936 | cid_5741389
Type:
Small organic molecule
Emp. Form.:
C16H11FN2O
Mol. Mass.:
266.2697
SMILES:
Fc1ccc(\C=C\c2nc3ccccc3[nH]c2=O)cc1
Structure:
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